ГоловнаArchive of numbers2020Volume 28, issue 1 (102)The effect of convulsive syndrome on the metabolic status and survival of patients with alcoholic delirium
Title of the article The effect of convulsive syndrome on the metabolic status and survival of patients with alcoholic delirium
Authors Zadorozhnyi Volodymyr
In the section DIAGNOSTICS AND THERAPY OF MENTAL AND NARCOLOGICAL DISORDERS
Year 2020 Issue Volume 28, issue 1 (102) Pages 47-50
Type of article Scientific article Index UDK 616.853.-008.441.13-06 Index BBK -
Abstract DOI: https://doi.org/10.36927/20790325-V28-is1-2020-10

 The aim of the study was to study the effect of convulsive syndrome in patients with delirium tremens (DT) on the charac teristics of the metabolic status of the body, the severity of clinical manifes tations, and survival of people of different ages. The study involved 753 patients with DT at the age of 20 to 76 years. The metabolic status was studied. One indicator was the urea-creatinine serum index; its low level was considered a sign of anabolic trends in metabolism. Another indicator was the determination of the total protein content in the body by daily excretion of creatinine. It was found that patients with DT with convulsive syndrome had a higher score according to the severity of the disease according to the DRS scale, a longer period of mental disorders, the average number of somatic complications was higher. However, the survival rate of patients with DT with convulsive syndrome and patients with DT without convulsive manifestations was the same. To determine the causes of this, the metabolic status and age of surviving and deceased patients with DT were compared. The highest total protein content in the body is observed in surviving patients with DT with manifestations of convulsive syndrome. Surviving patients with DT with manifestations of convulsive syndrome had a significantly lower level of urea-creatinine index compared with survivors with DT without convulsive syndrome. Among all patients with DT, the average age of survivors with convulsive syndrome was the lowest, and the average age of deceased patients with convulsive syndrome was the highest. In patients with DT without convulsive manifestations, the age of surviving and dead patients did not differ. The age of surviving patients with DT with convulsive syndrome is significantly lower than that of surviving patients without convulsive manifestations. The presence of convulsive syndrome and associated metabolic changes in the body in patients with DT contributes to the survival of a younger part of patients.
Key words alcohol delirium, seizures, aggravation of mental and somatic disorders, anabolic state of metabolism, primary survival of young patients
Access to full text version of the article pdf download
Bibliography 1. Hillbom M., Pieninkeroinen I., Leone M. Seizures in alcohol-dependent patients: epidemiology, pathophysiology and management // CNS Drugs. 2003; 17 (14): 1013—30. DOI: 10.2165/00023210-200317140-00002. 
2. Kanareykina I. L., Sharov M. N. Klinichesko-neyrofiziologicheskie osobennosti alkogolnogo sudorozhnogo sindroma // Vrach skoroy pomoschi. 2008. № 2. С. 49—52. 
3. Risk factors for lethal outcome in patients with delirium tremens — psychiatrist’s perspective: a nested case-control study / Ignjatovic-Ristic D., Rancic N., Novokmet S. [et al.] // Ann. Gen. Psychiatry. 2013; 12: 39. DOI: 10.1186/1744-859X-12-39. 
4. Visée H. The Relationship between Alcohol and Seizures: An Overview of the Major Data // Int J Neurorehabilitation. 2015. 2: 141. DOI: 10.4172/2376-0281.1000141. 
5. Rogawski M. A. Update on the Neurobiology of Alcohol Withdrawal Seizures // Epilepsy Curr. 2005 Nov; 5 (6): 225–230. DOI: 10.1111/j.1535-7511.2005.00071.x. 
6. Activity of hippocampal adult-born neurons regulates alcohol withdrawal seizures / Lee D., Krishnan B., Zhang H. [et al.] // JCI Insight. 2019 Oct 3; 4 (19). DOI: 10.1172/jci.insight.128770. 
7. Validation of the Delirium Rating Scale-revised-98: compa ri son with the delirium rating scale and the cognitive test for de lirium / Trzepacz P. T., Mittal D., Torres R. [et al.] // J Neuropsychiatry Clin Neurosci. 2001; 13: 229—242. DOI: 10.1176/jnp.13.2.229. 
8. Higgins C. Urea end creatinine concentration, the urea:creatinine ratio. 2016. URL: https://acutecaretesting.org/en/articles/ urea-and-creatinine-concentration-the-urea-creatinine-ratio.
9. Biohimiya i alkogolizm (V): razvitie belkovoy distrofii i patogenez alkogolizma / I. M. Roslyiy, S. V. Abramov, T. A. Shipiko [i dr.] // Voprosyi narkologii. 2004. № 6. С. 59—66. URL: https://elibrary.ru/contents.asp?issueid=10306 26&selid=1795378. 
10. The relationship of body composition and oxygen consumption and creatinine excretion in healthy and wasted men / Ryan R. J., Williams J. D., Ansell B. M. [et al.] // Metabolism: Clinical and Experimental. 1957. 66 (4): 365—377. PMID: 13451182.