ГоловнаArchive of numbers2020Volume 28, issue 1 (102)The cytokine system dysfunction in the acute period of ischemic stroke in dynamics of correction with cryopreserved cord blood serum
Title of the article The cytokine system dysfunction in the acute period of ischemic stroke in dynamics of correction with cryopreserved cord blood serum
Authors Lychko Volodymyr
In the section MECHANISMS OF FORMATION AND MODERN PRINCIPLES OF TREATMENT OF NEUROLOGICAL DISORDERS
Year 2020 Issue Volume 28, issue 1 (102) Pages 14-16
Type of article Scientific article Index UDK 616.831-005.8-085.38 Index BBK -
Abstract DOI: https://doi.org/10.36927/20790325-V28-is1-2020-3

The changes of the cytokine system in the dynamics of treatment of 350 patients in the acute period of ischemic stroke by cryopreserved cord blood serum (CCBS) “CryocellCryocord” were studied. This revealed simultaneous strong activation of pro- and anti-infl ammatory cytokines in debut of the disease confirms their direct relevance to the early initiation of local inflammatory changes in response to acute ische mic brain tissue damage. Positive dynamics of normalization of plasma cytokine levels in patients, who additionally received CCBS can testify about anti-inflammatory effect of CCBS.
Key words ischemia, cord blood, cytokine, inflammation, macrophage.
Access to full text version of the article pdf download
Bibliography 1. Lambertsen K. L., Biber K., Finsen B. Inflammatory cytokines in experimental and human stroke // Journal of Cerebral Blood Flow and Metabolism. 2012. Vol. 32, No. 9. P. 1677—1698. DOI: 10.1038/jcbfm.2012.88. 
2. Postischemic Inflammation in Acute Stroke / [Vidale S., Consoli A., Arnaboldi M., Consoli D.] // Journal of Clinical Neurology. 2017. Vol. 13, No. 1. P. 1—9. DOI: 10.3988/jcn.2017.13.1.1. 
3. The balance of interleukin (IL)-6, IL-6 center dot soluble IL-6 receptor (sIL-6R), and IL-6 center dot sIL-6R center dot sgp130 complexes allows simultaneous classic and trans-signaling / Baran P., Hansen S., Waetzig G. H. [et al.] // Journal of Biological Chemistry. 2018. Vol. 293, No. 18. P. 6762—6775. DOI: 10.1074/ jbc.RA117.001163. 
4. Soluble gp130 prevents interleukin-6 and interleukin-11 cluster signaling but not intracellular autocrine responses / Lamertz L., Rummel F., Polz R. [et al.] // Science Signaling. 2018. Vol. 11, Issue 550. eaar7388. DOI: 10.1126/scisignal.aar7388. 
5. Mattingly A. J., Laitano O., Clanton T. L. Epinephrine stimulates CXCL1 IL-1 alpha, IL-6 secretion in isolated mouse limb muscle // Physiological Reports. 2017. Vol. 5, No. 23. e13519. DOI: 10.14814/phy2.13519. 
6. Esenwa C. C., Elkind M. S. Inflammatory risk factors, biomarkers and associated therapy in ischaemic stroke // Nature Reviews Neurology. 2016. Vol. 12, No. 10. P. 594—604. DOI: 10.1038/nrneurol.2016.125. 
7. Changes in the cellular immune system and circulating inflammatory markers of stroke patients / Jiang C., Kong W. X., Wang Y. J. [et al.] // Oncotarget. 2017. Vol. 8, No. 2. P. 3553—3567. DOI: 10.18632/oncotarget.12201. 
8. Systemic inflammation reverses stroke-induced changes in astrocytic aquaporin-4 expression / Sun Y., Matthew D., Spychala M. [et al.] // Stroke. 2016. Vol. 47. ATP 452. 
9. Interleukin-4 is essential for microglia/macrophage M2 polarization and long-term recovery after cerebral ischemia / Liu X. R., Liu J., Zhao S. F. [et al.] // Ibid. 2016. Vol. 47, No. 2. P. 498—504. DOI: 10.1161/STROKEAHA.115.012079. 
10. Protective effects of an anti-inflammatory cytokine, interleukin-4, on motoneuron toxicity induced by activated microglia / Zhao W. H., Xie W. J., Xiao Q. [et al.] // Journal of Neurochemistry. 2006. Vol. 99, No. 4. P. 1176—1187. DOI: 10.1111/j.1471-4159.2006.04172.x. 
11. Reducing Th2 inflammation through neutralizing IL-4 antibody rescues myelination in IUGR rat brain / Zanno A. E., Romer M. A., Fox L. [et al.] // Journal of Neurodevelopmental Disorders. 2019. Vol. 11, No. 1. P. 1—13. DOI: 10.1186/s11689- 019-9297-6. 
12. Role of interleukin-10 in acute brain injuries / Garcia J. M., Stillings S. A., Leclerc J. L. [et al.] // Frontiers in Neurology. 2017. Vol. 8, No. 244. P. 1—17. DOI: 10.3389/fneur.2017.00244. 
13. Segev-Amzaleg N., Trudler D., Frenkel D. Preconditioning to mild oxidative stress mediates astroglial neuroprotection in an IL-10-dependent manner // Brain Behavior and Immunity. 2013. Vol. 30. P. 176—185. DOI: 10.1016/j.bbi.2012.12.016. 
14. Anrather J., Iadecola C. Inflammation and stroke: an overview. Neurotherapeutics. 2016. Vol. 13, No. 4. P. 661—670. DOI: 10.1007/s13311-016-0483-x. 
15. Monocyte-derived macrophages contribute to spontaneous long-term functional recovery after stroke in mice / Wattananit S., Tornero D., Graubardt N. [et al.] // Journal of Neuroscience. 2016. Vol. 36, No. 15. P. 4182—4195. DOI: 10.1523/JNEUROSCI.4317-15.2016. 
16. Link between interleukin-10 level and outcome after ischemic stroke / Chang L. T., Yuen C. M., Liou C. W. [et al.] // Neuroimmunomodulation. 2010. Vol. 17, No. 4. P. 223—228. DOI: 10.1159/000290038. 
17. Goltsev A. N., Lebedinets D. V., Porozhan E. A. Vliyanie kriokonservirovannyih kletok embrionalnogo mozga na mediatoryi vospaleniya pri eksperimentalnom ishemicheskom insulte // Problemyi kriobiologii. 2008. T. 18, No. 3.C. 309-312. 
18. Human umbilical cord mesenchymal stem cells preserve adult newborn neurons and reduce neurological injury after cerebral ischemia by reducing the number of hypertrophic microglia/macrophages / Lin W., Hsuan Y. C., Lin M. T. [et al.] // Cell Transplant. 2017. Vol. 26, No. 11. P. 1798—1810. DOI:10.1177/0963689717728936.