ГоловнаArchive of numbers2020Volume 28, issue 1 (102)Pregnancy progression, childbirth and postpartum period in women on the preclinical stage and against the background of multiple sclerosis in sporadic and family forms
Title of the article Pregnancy progression, childbirth and postpartum period in women on the preclinical stage and against the background of multiple sclerosis in sporadic and family forms
Authors PogulyaevaTetiana
In the section MECHANISMS OF FORMATION AND MODERN PRINCIPLES OF TREATMENT OF NEUROLOGICAL DISORDERS
Year 2020 Issue Volume 28, issue 1 (102) Pages 36-41
Type of article Scientific article Index UDK 616.832-004.2:618.3+392.122-036.1 Index BBK -
Abstract DOI: https://doi.org/10.36927/20790325-V28-is1-2020-8


 For the fi rst time in Ukraine, was explored the eff ect of pregnancy, childbirth and the postpartum period on the further course of multiple sclerosis (MS) in sporadic and family forms of women giving birth at the preclinical stage (group 1) and against the background of the disease (group 2). Through the use of questioning method and clinical and neurological examination the following phenomena were studied. Namely, premonitory history; features of the course of the disease; the duration between labor and development of the onset of the illness in women of the 1st group and between the onset and labor in women of the 2nd group; obstetric and gynecological history; the eff ect of pregnancy and childbirth on the further course of MS. A total of 82 women were examined, 51 of them were giving birth at preclinical stage (group 1) and 31 — against the background of MS (group 2). In the 1st group with remitting course (RC), 26 women had a sporadic form and 5 — a family form; with progressive course (PC) — in 14 — sporadic and in 6 — family form. In the 2nd group with RC, 23 women had sporadic and 1 family form; with PC — 6 had sporadic and 1 family. Research has shown, the disease of majority of women from the first group has been developed after childbirth. Women from the second group with RC were giving birth most often after 5—10 years of the disease onset; with PC — after more than 10 years. According to the obstetric and gynecological history, differences were obtained during pregnancy, childbirth and the postpartum period between two groups of women with different types of course. An assessment of the effects of pregnancy, childbirth and the postpartum period of women from the 2nd group made it possible to identify criteria for various options for the further course of MS (such as improvement, stabilization, improvement through worsening, worsening), which are closely interrelated with the types of course of the disease. To sum up, an integrated analysis of the above mentioned outcome shows a positive eff ect of pregnancy and childbirth in the vast majority of women with RC and a high incidence of decline of women with PC.
Key words multiple sclerosis, types of course, sporadic and familial form, pregnancy and childbirth, obstetric and gynecological history, complications during pregnancy and childbirth
Access to full text version of the article pdf download
Bibliography 1. Zavalishin I.A., Nevskaya O.M. Rasseyannyiy skleroz i beremennost // Mediko-sotsialnyie aspektyi rasseyannogo skleroza : materialyi nauch. konf. CPb., 2001. S. 35—36. 
2. Shmidt T. E., Yahno N. N. Rasseyannyiy skleroz. 5 izd-e. M. : MEDpress-inform, 2016. S. 147—157; 239—242. 
3. Multiple sclerosis and pregnancy: experience from a nationwide database in Germany / [K. Hellwig, A. Haghikia, M. Rockhoff, and R. Gold] // Ther Adv Neurol Disord. 2012 Sep. № 5 (5). Р. 247—253. DOI: 10.1177/1756285612453192. 
4. Retrospektivnyiy analiz techeniya beremennosti i rodov u zhenschin s rasseyannyim sklerozom / E. V. Popova, T. M. Kukel, A. I. Muravin [i dr. ] // Zhurnal nevrologii i psihiatrii im. S. S. Korsakova. 2013. # 113 (10). S. 52—56. 
5. Yakushina T. I., Kotov S. V., Yakushin M. A. Analiz techeniya beremennosti, rodov i poslerodovogo perioda u zhenschin s rasseyannyim sklerozom // Almanah klinicheskoy meditsinyi. 2015. № 39. R. 82—88. URL: https://doi.org/10.18786/2072-0505-2015-39-82-89
6. Belova A. N., Kachalina T. S., Krupin V. N. Rasseyannyiy skleroz i beremennost // Nevrologicheskiy zhurnal. 2010. № 6. S. 4—10. 
7. Negry`ch T. I., Shorobura M. S., Negry`ch N. O., Shhur M. B. Osobly`vosti perebigu rozsiyanogo sklerozu v zhinok u period vagitnosti ta vply`v patogenety`chnogo likuvannya na stan ploda j novonarodzhenogo // Mizhnarodny`j nevrologichny`j zhurnal.2013. № 1. С. 11—16. URL: http://www.mif-ua.com/archive/article/35226
8. Negry`ch T. I., Ory`nchak L. B. Osobly`vosti perebigu rozsiyanogo sklerozu v zhinok zalezhno vid narodzhennya ditej //Tam samo. 2015. № 5 (75). S. 45—52. URL: http://nbuv.gov.ua/UJRN/Mnzh_2015_5_8 
9. Ory`nchak L. B. Vply`v vagitnosti ta grudnogo vy`godovuvannya na perebig rozsiyanogo sklerozu // Ukrayins`ky`j nevrologichny`j zhurnal. 2015. № 2. S. 31—36. 
10. Does pregnancy alter the long-term course of multiple sclerosis? / Karp I., Manganas A., Sylvestre M. P. [et al.] // Annals of Epidemiology. 2014. № 24. С. 504—508. DOI: 10.1016/j.annepidem.2014.04.007. 
11. Voloshina N. P., Vasilovskiy V. V., Chernenko M. E. Vliyanie infektsionnogo faktora na sostoyanie gematoentsefalicheskogo barera u bolnyih rasseyannyim sklerozom // Ukrayins`ky`j visny`k psy`xonevrologiyi. 2013. Т. 21, вип. 1 (74). С. 5—7. 
12. Klinicheskaya harakteristika debyutov rasseyannogo skleroza pri raznyih tipah techeniya s uchetom tekuschego prognoza / N. P. Voloshina, T. V. Negreba, I. L. Levchenko [i dr.] // Ukrayins`ky`j nevrologichny`j zhurnal. 2013. № 4 (29). С. 7—13. URL: http://nbuv.gov.ua/UJRN/UNJ_2013_4_3. 13. Prognosty`chni kry`teriyi pry` rizny`x ty`pax perebigu rozsiyanogo sklerozu / N. P. Voloshy`na, T. V. Negreba, I. L. Levchenko, T. M. Tkachova, O. V. Yegorkina // Avtors`ke pravo na naukovy`j tvir № 39160 vid 14.07.2011 r. 
14. Novi pidxody` do klinichnoyi diagnosty`ky` rizny`x ty`piv perebigu rozsiyanogo sklerozu i yix dy`ferencijovana terapiya. Prakty`chni rekomendaciyi / N. P. Voloshy`na, T. V. Negreba, V. V. Vasy`lovs`ky`j, I. L. Levchenko, O. V. Yegorkina, T. M. Tkachova, M. Ye. Chernenko, I. K. Gaponov // Svidocztvo pro reyestraciyu avtors`kogo prava na naukovy`j tvir # 47786 vid 13.02.2013 r. 
15. Sravnitelnaya klinicheskaya harakteristika raznyih tipov techeniya semeynyih i sporadicheskih form rasseyannogo skleroza / N. P. Voloshina, T. V. Negreba, V. V. Vasilovskiy[i dr.] // Ukrayins`ky`j visny`k psy`xonevrologiyi. 2018. Т. 26, вип. 1 (94). С. 10—19. 
16. Negreba T. V. Techenie i prognoz sovremennyih form rasseyannogo skleroza // Svidocztvo pro reyestraciyu avtors`kogo prava na naukovy`j tvir № 30251 vid 15.09.2009.