ГоловнаArchive of numbers2019Volume 27, issue 4 (101)Clinical-psychopathological and medical-social characteristics of patients with endogenous psychoses with an episodic course in the context of post-manifestation pathopersonological transformations
Title of the article Clinical-psychopathological and medical-social characteristics of patients with endogenous psychoses with an episodic course in the context of post-manifestation pathopersonological transformations
Authors Khomitskyi Mykola
In the section DIAGNOSTICS AND THERAPY OF MENTAL AND NARCOLOGICAL DISORDERS
Year 2019 Issue Volume 27, issue 4 (101) Pages 75-78
Type of article Scientific article Index UDK 616.895-039.33-06:616.89-008.485]-07 Index BBK -
Abstract The determination of the nosological affi liation of a separate clinical case in the group of endogenous psychoses is a decisive factor in adequate psychopharmacotherapy. The clinical aspects of post-manifestation pathopersonological transformations of endo genous psychosis with an episodic course remain the least studied and require study to improve the quality of diff erential diagnosis, treatment and rehabilitation. The aim of this study was to conduct a comparative analysis of personal characteristics, types of attitude toward the disease and adaptability of patients with schizophrenia and schizoaff ective disorder. On the basis of the Regional Clinical Psychiatric Hospital (Zaporizhzhia, Ukraine), 312 patients were examined, among them 102 patients with aff ective disorders; 102 patients suffering from schizoaffective disorder and 108 patients diagnosed with schizo phrenia, paranoid form, episodic course. The main research methods were clinical-psychopathological, clinical-follow-up, clinical-anamnestic and medical-social, as well as medicalstatistical analysis. The study revealed signs and nosospecifi c diff erences in indicators of social (labor and family) maladjustment, as well as positive, negative and general psychopathological disorders (according to PANSS) in endogenous psychoses with an episodic course, confi rming the presence of post-manifestation pathopersonological transformations. In the group of endogenous psychosis with an episodic course, pathopersonological transformations in schizoaff ective disorder are characterized by the most complex structure and are a nosospecific marker. Further studies of remission/intermission in endo genous psychosis open up the possibility of developing a differential diagnostic system and algorithms for providing personalized medical and rehabilitation care.
Key words schizoaffective disorder, aff ective disorders, schizophrenia, clinic, social maladjustment, diff erential diagnosis, pathopersonological transformations
Access to full text version of the article pdf download
Bibliography

1. Long-term trajectories of positive and negative symptoms in first episode psychosis: A 10year follow-up study in the OPUS cohort / Austin S. F., Mors O., Budtz-Jоrgensen E. [et al.] // Schizophrenia Research. 2015. Vol. 168. P. 84—91. DOI: 10.1016/j. schres.2015.07.021.
2. Diagnostic reliability in schizoaffective disorder / Murru A., Manchia M., Tusconi M. [et al.] // Bipolar Disorder. 2016. Vol. 18(1). P. 78—80. DOI: 10.1111/bdi.12366.
3. Test-retest reliability of schizoaffective disorder compared with schizophrenia, bipolar disorder, and unipolar depression — a systematic review and meta-analysis / [Santelmann H., Franklin J., Bu.hoff J., Baethge С.] // Ibid. 2015. Vol. 17(7). P. 753—768. DOI: 10.1111/bdi.12340.
4. Maruta N. O., Yaroslavtsev S. O. Shizofreniya s komorbidnyimi psihicheskimi i povedencheskimi rasstroystvami (struktura komorbidnoy patologii, kriterii diagnostiki, faktoryi prognoza i zakonomernosti formirovaniya) // Medichna psihologIya. 2015. № 4. S. 46—50.
5. Long-term outcome of schizoaffective disorder. Are there any differences with respect to schizophrenia? / Pinna F., Sanna L., Perra V. [et al.] ; Cagliari Recovery Study Group // Rivista di Psichiatria. 2014. Vol. 49 (1). P. 41—49. DOI: 10.1708/1407.15624.
6. Wilson J. E., Nian H., Heckers S. The schizoaffective disorder diagnosis: a conundrum in the clinical setting // European Archives of Psychiatry and Clinical Neuroscience. 2014. Vol. 264(1). P. 29—34. DOI: 10.1007/s00406-013-0410-7.
7. Petho B. Concepts of Schizo-affective psychoses. History, construct validity and some empirical data // Psychiatrу Clin. 1983. Vol. 16 (2—4). P. 71—86. PMID: 6622738.
8. Uchebnik psihiatrii dlya vrachey i studentov / Emil Krepelin ; per. s 8-go nem. pererab. izd. vrachey Pokrovskoy Zemskoy Psihiatricheskoy bolnitsyi Galunova, Ivensena, Tartakovskogo i Tsvetaeva. T. 1. Moskva, 1910. 468 s.
9. Khomitskyi M. Ye. Psykhopatolohichni proiavy endohennykh psykhoziv u stanakh remisii/intermisii yak predyspozytsiinyi faktor personolohichnykh transformatsii (komparatyvnyi analiz) // Zaporizkyi medychnyi zhurnal. 2018. T. 20, № 5(110). S. 696—700.