ГоловнаArchive of numbers2019Volume 27, issue 3 (100) The role of single nucleotide polymorphism Val66Met in BDNF gene in the formation of end points after ST segment elevation myocardial infarction
Title of the article The role of single nucleotide polymorphism Val66Met in BDNF gene in the formation of end points after ST segment elevation myocardial infarction
Authors Petyunina Olga
Kopytsya Mykola
Skrynnyk Olga
In the section MECHANISMS OF FORMATION AND MODERN PRINCIPLES OF TREATMENT OF NEUROLOGICAL DISORDERS
Year 2019 Issue Volume 27, issue 3 (100) Pages 19-25
Type of article Scientific article Index UDK 616.127-005.8-092:575.113.2-021.25 Index BBK -
Abstract The purpose of this study was to research the possible associations of single-nucleotide polymorphism of Val66Met BDNF gene with the occurrence of endpoints after 6 months of follow-up after a myocardial infarction with ST elevation segment — ST segment elevation myocardial infarction (STEMI). To participate in the study, 256 patients which met all the inclusion criteria were hospitalized in the department of intensive care, State Institution “L. T. Malaya Therapy National Institute NAMSU” from January 2016 to February 2019. Blood fl ow to all patients was restored at the level TIMI III. The frequency of genotypes Val66Met gene for BDNF in STEMI patients (n = 256) was the following: 66ValVal — 74.2 % (n = 190), 66ValMet + 66MetMet — 25.8 % (n = 66). The study of single-nucleotide polymorphism of Val66Met gene BDNF (rs6265) was performed by real-time polymerase chain reaction using the “TacMan TMSNP Genotyping Assays” production of Thermo Fisher Scientifi c Assay IDC_11592758_1. The emotional state of the patients and its relationship with stress were assessed with the questionnaire “Depression, Anxiety and Stress Scale-21”. It turned out that the 66ValMet + 66MetMet polymorphism of the BDNF gene, stress and anxiety 10—14 days before the event, as well as reduced left ventricular ejection fraction, are associated with an unfavorable prognosis of the combined end point 6 months after STEMI and are its independent predictors.
Key words STEMI, polymorphism Val66Met of BDNF gene, prognosis
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