ГоловнаArchive of numbers2015Volume 23, issue 2 (83)Clinical potential of asymptomatic brain damages (review of literature)
Title of the article Clinical potential of asymptomatic brain damages (review of literature)
Authors Nikishkova Iryna
In the section DIAGNOSTICS AND THERAPY OF NEUROLOGICAL DISORDERS
Year 2015 Issue Volume 23, issue 2 (83) Pages 22-26
Type of article Scientific article Index UDK 616.831-005:616.8:616.89-071 Index BBK -
Abstract The article is devoted to the problem of clinical potential of asymptomatic brain damages and their role in formation of severe medical conditions resulting in disability an early mortality. Asymptomatic brain damages, particularly silent brain infarcts, are registered up to 5—10 more often than stroke and their prevalence in some cohorts may achieve 62 %. An analysis of data from population studies confi rms that in the general population silent brain infarcts increase risk of stroke more than twice, as well as influence on a functional outcome and formation of disability after stroke. Asymptomatic brain damages are a strong predictor of cognitive dysfunction with a high rate of transition from a mild level of cognitive decline to vascular dementia. Among patients with pre-senile and senile major depression a prevalence of silent brain infarcts is high, and moreover, number and localization of silent brain infarcts are independent risk factors for development of depression with a late onset. The data presented in the article evidence that a clinical potential of asymptomatic brain infarcts is associated with a poor qua li ty of life and a signifi - cant economic burden, as subclinical cerebrovascular events independently or indirectly increase a possibility of formation of stroke, vascular dementia, and depression. Despite of a steady opinion about a predominate strengthening of influence of asymptomatic brain damages with age, there is a problem of comorbidity of these damages. This stipulates a necessity of evaluation for presence of subclinical cerebrovascular events independently from age.
Key words silent brain infarct, white matter lesions, risk factor, stroke, cognitive impairments, dementia, depression
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