ГоловнаArchive of numbers2014Volume 22 , issue 4 (81)Psychoneurological follow up development in infants after surgical correction of transposition of great arteries associated with HIF-1α and S100β in the blood
Title of the article Psychoneurological follow up development in infants after surgical correction of transposition of great arteries associated with HIF-1α and S100β in the blood
Authors Kasianova Anastasiia Yuriivna
Zhovnir Volodymyr Apollinariiovych
Markova Marianna
Vorobyova Anna Myhailivna
Yemets Illya Mykolayovych
In the section DIAGNOSTICS AND THERAPY OF MENTAL DISORDERS
Year 2014 Issue Volume 22 , issue 4 (81) Pages 69-71
Type of article Scientific article Index UDK 616.899-053.2-02+ [616.132+616.141]-053.2-089-06+616.153.96-053.2 Index BBK -
Abstract Our research goal was to determine the link between the psychoneurological follow up in infants after the transposition of great arteries (TGA) surgical correction and HIF-1α and S100β in the blood of newborns. 20 children with TGA who underwent the arterial switch operation on the early stages of their life, took part in the study. Molecular study has been conducted before the surgery as well as on the 1st and 7th day after it. The Bayley Scales of Infant Development method was used to study infants psychoneurological development at the age of 1 and 3 years. Based on the indices of mental and psychomotor development of 1 and 3 year old infants, autologous placental umbilical cord blood was used during the surgery and those infants produced much better results compared with another group where the donor blood was used. The study of the link between psychoneurological follow up development of infants after TGA surgery and HIF-1α hypoxia factor and S100β protein in the blood showed the high index of hypoxia factor HIF-1α has no relation to the worsening of psychomotor development in the follow up period and needs further research. At the same time, the glial-derived S100β protein can be a more likely marker to determine the potential retardation of psychomotor development of infants in the future.
Key words infants, congenital heart disease, psychomotor development, biomarkers.
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