ГоловнаArchive of numbers2014Volume 22, issue 3 (80)Diagnosis and treatment of epilepsy in children with autism spectrum disorders
Title of the article Diagnosis and treatment of epilepsy in children with autism spectrum disorders
Authors Martsenkovskyi Igor
In the section DIAGNOSTICS AND THERAPY OF NEUROLOGICAL AND MENTAL DISORDERS IN CHILDREN
Year 2014 Issue Volume 22, issue 3 (80) Pages 121-126
Type of article Scientific article Index UDK 159.973+616.853-07+085.2/3 Index BBK -
Abstract Epilepsy is diagnosed in 11— 25 % of patients with autism spectrum disorders (ASD). Specific for epilepsy EEG changes are observed in 20—39 % of patients with autism. Epileptic process may precede the pervasive developmental disorder in the framework the autistic epileptiform regression. ASD may be complicated by seizures. Epilepsy and ASD can be the manifestations of a single disease process leading to disruption of brain development. The aim of the study was to identify the most effective and safe anti-epileptic drugs and other treatments for epilepsy in children with ASD. Were randomized 1535 of children. All antiepileptic drugs (AED) have shown a positive effect on seizures and on ASD symptoms. Valproate, lamotrigine, leve tiracetam and ethosuximide have shown a wide spectrum of activity against epileptic seizures and acceptable level of side effects. Some traditional methods of treatment of epilepsy that do not belong to the AED, such as the ketogenic diet, have positive effect both on seizures and some autistic manifestations. Gluten-free and casein free diet positively affect the ASD, but do not significantly affect the seizures.
Key words antiepileptic drugs, gluten free diet, casein free diet, autism spectrum disorder, epilepsy, autistic epileptiform regression, seizures
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