ГоловнаArchive of numbers2014Volume 22, issue 2(79)Inluence of some infusion solutions on indices of energy metabolism in rats brain on the model of acute cerebral ischemia
Title of the article Inluence of some infusion solutions on indices of energy metabolism in rats brain on the model of acute cerebral ischemia
Authors Semeneko Andrii Igorovych
Kondratskyi Bogdan Oleksiiovych
Kobeliatskyi Yurii Yuriiovych
In the section DIAGNOSTICS AND THERAPY OF NEUROLOGICAL DISORDERS
Year 2014 Issue Volume 22, issue 2(79) Pages 48-51
Type of article Scientific article Index UDK 615.384:616.831-005.4-001.6 Index BBK -
Abstract In investigations on the rats with model acute disorder of the cerebral circulation (bilateral ligation of internal carotid arteries) was stablished that injection of colloid isoosmolar solution of voluven and colloid hyperosmolar solu-tion of HAES-LX-5 % in a dose 2,5 ml/kg 2  times a day (5,0  ml/kg per day), ev-eryday every 12  hours during 7  days of observation accompanied by more sig-nii cant decreasing of energy dei ciency, processes of anaerobic glycolysis and improving of aerobic oxidation of glu-cose in the ischemic brain of the animals (р  <  0.05) comparing with therapy of 0,9  % NaCl solution (in the same dose).Therapy of voluven solution was comparable to infusion of HAES-LX-5 % (р  >  0.05) by ability to decrease mani-festations of energy dei ciency during 7  days of insult.
Key words acute disorder of the ce-rebral circulation, HAES-LX-5 %, voluven, 0,9  % NaCl solution
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Bibliography 1. Gusev E.I., Skvortsova V.I. Cerebral ischemia [Ishemiia golovnogo mozga]. Moscow: Meditsina Publ., 2001. 328 p.
2. Karzin A.V. Features of infusion therapy for acute diseases and injuries of the brain, accompanied by intracranial hemorrhages. Author’s abstract. [Osobennosti infuzionnoi terapii pri ostrykh zabolevaniiakh i povrezhdeniiakh golovnogo mozga, soprovozhdaiushchikhsia vnutricherepnymi krovoizliianiiami: dis. na soiskanie uch. stepeni kand. med. nauk: spets. 14.00.37; 14.00.28]. Moscow, 2003. 129 p.
3. Nikonov V.V., Savitskaia I.B. The role of glutamate receptor antagonists (PK-Merz) in the treatment of brain injury (review). [Rol' antagonistov glutamatnykh retseptorov (PK-Merts) v lechenii povrezhdenii mozga (obzor literatury)]. Meditsina neotlozhnykh sostoianii - Medicine of emergency states, 2012. No. 5(44). Pp. 36-40.
4. Prokhorova M.I. Modern methods of biochemical researches. [Sovremennye metody biokhimicheskikh issledovanii]. Leningrad: Leningrad University Publ., 1982. 272 p.
5. Troshin V.D., Brovkov N.N. Emergency cardioneurology. [Neotlozhnaia kardionevrologiia]. Moscow: Meditsinskoe informatsionnoe agentstvo Publ., 2010. 672 p.
6. Hodakivskiy O.A. The influence of ademolu on indicators of energy metabolism in the brain of rats with a model of acute cerebral ischemia. [Vpliv ademolu na pokazniki energetichnogo obminu v golovnomu mozku shchuriv iz modellyu gostroyi tserebralnoyi ishemiyi]. Bukovinskiy medichniy visnik - Bukovinian medical bulletin, 2013. No. 2 (66). Vol. 17. Pp. 140-143.
7. Shvedskiy V.V., Shtrigol S.Yu., Merzlikin S.I. The influence of diacamph hydrochloride on the indicators of energy metabolism in the brain of rats with a model of cerebral ischemia on the background of diabetes mellitus. [Vpliv diakamfu gidrohloridu na pokazniki energetichnogo obminu v golovnomu mozku shchuriv iz modellyu tserebralnoyi ishemiyi na tli tsukrovogo diabetu]. Klinichna farmatsiya - Clinical pharmacy, 2011. Vol. 15, no. 3. Pp. 57-61.
8. Belenichev I.F., Kolesnik Yu.M., Pavlov S.V. Malate-aspartate shunt in neuronal adaptation to ischemic conditions: molecular-biochemical mechanisms of activation and regulation. Neurochemical Journal, 2012. Vol. 6, no.1. Рp. 22-28.