ГоловнаArchive of numbers2019Volume 27, issue 1 (98)Sensitivity of cognitive functions to the burden of cerebral small vessel disease
Title of the article Sensitivity of cognitive functions to the burden of cerebral small vessel disease
Authors Nikishkova Iryna
Mishchenko Vladyslav
Kutikov Damir
Year 2019 Issue Volume 27, issue 1 (98) Pages 20-26
Type of article Scientific article Index UDK 616.831-005:616.89-008-06 Index BBK -
Abstract The cerebral small vessel disease (сSVD) is one of the main causes of cognitive decline. The quantity/quality of MRI-sings of the disease can aff ect the profi le of diff erent cognitive domains involved in pathological changes. The main group (MG) consisted of 50 patients (including 30 women) aged 45 to 72 years (mean age 62.05 ± 1.46 years) with MRI signs of cSVD and without history of stroke. The MG was divided into 2 subgroups according to the scale of the "total score for the cSVD": 1st with patients (n = 20) with 1—2 points of the cSVD burden, and 2nd with patients (n = 20) with 3—4 points of the cSVD burden. The control group (CG) consisted of 20 practically healthy persons (including 12 women) aged 48—76 years (mean age 57.36 ± 3.79 years). In both groups, the state of cognitive functions was studied by means of computer neurocognitive testing (CNT) on a tablet personal computer (PC) with a touch-screen with using of Tempus Test Set battery consisted of "odd-ball" task, Go/NoGo task, Eriksen Flanker task, Stroop eff ect, Numerical Stroop eff ect, continuous recognition task. To investigate the neurophysiological components of cognitive functioning during the performance of odd-ball tasks in both groups, cognitive- induced event-related potentials (ERP) were studied. The results of CNT and ERP showed a sensitivity to the burden of cSVD. This sensitivity was manifested in a tendency to decrease the effi ciency of passing of tests and increase of the amount of affected cognitive functions with an increase in the score of the cSVD scale. Attention (vigilance, selectivity, concentration, retention), information processing speed, and executive functions (cognitive fl exibility, planning and control of actions) were a most vulnerable to the cSVD and a sensitive to the cSVD burden. The emotional component contributes substantially to the cognitive changes in cSVD. For patients with cSVD, the CNT by means of a tablet PC with a touch screen is an accurate, fast, cost-eff ective method for assessing and monitoring of cognitive impairment.
Key words cerebral small vessel disea se, burden of disease, cognitive functions, computerized neurocognitive tes ting
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