ГоловнаArchive of numbers2018Volume 26, issue 2 (95)The problem of diagnosis and therapy of autoimmune encephalitis
Title of the article The problem of diagnosis and therapy of autoimmune encephalitis
Authors Yegorkina Olga
Voloshyna Natalia
In the section PROBLEMATIC ARTICLES
Year 2018 Issue Volume 26, issue 2 (95) Pages 5-12
Type of article Scientific article Index UDK 616.831-002-07.08:612.017.1 Index BBK -
Abstract Autoimmune encephalitis (AE) is a neurological disease characterized with damages of grey matter predominantly. In the pathogenesis of AE, the main role belongs to autoantibodies to intra- or extra structures of the nervous system, as antigens. Along with an integral examination, including neuroimaging, electroencephalography, investigation of cerebrospinal fl uid, and detection of antibodies to NMDA receptors, in some cases a search of oncological markers or nidi should be added to the diagnostic algorithm. A therapeutic algorithm for AE includes a combined prescription of glucocorticosteroid therapy, plasmapheresis, immunoglobulins, cytostatics, monoclonal anti bodies, as well as surgical interventions if an oncological process is revealed in some cases.
Key words autoimmune encephalitis, NMDA receptors, diff erential diagnosis, neurological impairments, mental health impairments, combined therapy
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