ГоловнаArchive of numbers2017Volume 25, issue 3 (92)Cognitive impairments in cerebral small vessel disease
Title of the article Cognitive impairments in cerebral small vessel disease
Authors Mishchenko Tamara
Nikishkova Iryna
Mishchenko Vladyslav
Kutikov Damir
Year 2017 Issue Volume 25, issue 3 (92) Pages 8-12
Type of article Scientific article Index UDK 616.831-005:616.89-008-037 Index BBK -
Abstract The article is devoted to an investigation of association of cognitive impairments (CIs) with MRI-markers of cerebral small vessel disease (cSVD), with cerebral atrophy (CA), and with the total сSVD burden. In the retrospective cohort study of 308 patients (from 50 to 85 years old; mean age 64.54 ± 0.45 years) with MRI sings of cSVD, prevalence of CIs was 80.19 % (p < 0.0001). Along with these, the revealed CIs were not connected with the patients’ ageing. Mild CIs were the most prevalent ones (69.48 %; p < 0.0001), whereas severe CIs were the least prevalent ones (0.65 %; p < 0.0001). In patients with mild CIs silent brain infarcts were the most prevalent (64.49 %; p < 0.0001), in patients with moderate CIs cases of severe/deep wait matter lesions were predominant (74.19 %; p < 0.0001). In cSVD the CIs were associated with cSVD burden. An increase of the burden score resulted in a decreasing of a cognitive productivity according to Montreal Cognitive Assessment (МоСА) points: from 24.96 of MoCA points in 0 of cSVD burden points to 19.40 of MoCA points in 4 of cSVD burden points (p < 0.0001). In patients with CA, the mean MoCA points were lower than ones in patients without CA (22.07 ± 0.29 vs. 24.63 ± 0.38; p < 0.0001). In cSVD a probability of mild CIs might be assessed by means of the logit-model developed by us with good sensitivity (77.57 %) and good specifi city (74.47 %).
Key words cerebral small vessel disease, cognitive impairments, burden, MRI markers, visible perivascular space, leucoaraiosis, silent brain infarct, cerebral microbleeding, cerebral atrophy
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